Fever
Lameness
Headache
Fatigue
Malaise
Sore throat
Painful oral lesions
Non-itchy body rash, followed by sores with blisters on palms of hands and soles of feet
Oral ulcer

Sores or blisters may be present on the buttocks of small children and infants
Irritability in infants and toddlers
Loss of appetite.
Diarrhea